Compositions for treating respiratory viral infections and their use
US8691781B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 4, 2005 |
| Grant date | Apr 8, 2014 |
| Priority date | — |
| Expiry date | Jul 29, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/18511
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides siRNA compositions that interfere with viral replication in respiratory viral infections, including respiratory syncytial virus and avian influenza A, including the H5N1 strain. The invention further provides uses of the siRNA compositions to inhibit expression of viral genes in respiratory virus-infected cells, and to uses in the treatment of respiratory virus infections in a subject. Generally the invention provides polynucleotide that includes a first nucleotide sequence of 15 to 30 bases that targets the genome of a respiratory syncytial virus or an influenza A virus, a complement thereof, a double stranded polynucleotide or a hairpin polynucleotide. Additionally the invention provides vectors, cells and pharmaceutical compositions containing siRNA sequences.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.