Solid pharmaceutical dosage form

US8691878B2 · kind B2 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• Jeorg Rosenberg · Ellerstadt, DE
• Ulrich Reinhold · Heidelberg, DE
• Bernd Liepold · Dossenheim, DE
• Gunther Berndl · Herxheim, DE
• Joerg Breitenbach · Mannheim, DE
• Laman Alani · Morristown, US
• Soumojeet Ghosh · Gurnee, US

Key dates

• Filing date: Nov 12, 2012
• Grant date: Apr 8, 2014
• Expiry date: Nov 12, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/1635
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A solid pharmaceutical dosage form providing improved oral bioavailability is disclosed for inhibitors of HIV protease. In particular, the dosage form comprises a solid dispersion of at least one HIV protease inhibitor and at least one pharmaceutically acceptable water-soluble polymer and at least one pharmaceutically acceptable surfactant, said pharmaceutically acceptable water-soluble polymer having a Tg of at least about 50° C. Preferably, the pharmaceutically acceptable surfactant has an HLB value of from about 4 to about 10.