Methods of chemical synthesis of diaminophenothiazinium compounds involving the use of persulfate oxidants
US8691979B2 · kind B2 · utility
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Key dates
| Filing date | May 11, 2010 |
| Grant date | Apr 8, 2014 |
| Priority date | — |
| Expiry date | Nov 13, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C381/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described are methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylhioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: a thiosulfonic acid formation (TSAF); an oxidative coupling (OC); and a ring closure (RC). Also described are resulting compounds and compositions comprising them (e.g., tablets, capsules) for use in methods of medical treatment and diagnosis, etc., for example, for tauopathies, or Alzheimer's disease (AD).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.