Patent · US Active

Acid addition salts of 5-aminolevulinic acid or its derivatives

US8692014B2 · kind B2 · utility

1Cited by

8References

24Claims

0Family size

Assignee

PHOTOCURE ASA · NO

Inventors

Jon Erik Braenden · Oslo, NO
Aslak Godal · Oslo, NO
Nils Olav Nilsen · Oslo, NO
Jo Klaveness · Oslo, NO

Key dates

Filing date	Oct 29, 2010
Grant date	Apr 8, 2014
Priority date	—
Expiry date	Feb 6, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C229/22
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides an acid addition salt of 5-aminolevulinic acid (5-ALA) or of a 5-ALA derivative (e.g. a 5-ALA ester) with an acid which has a pKa of about 5 or less, preferably about 3 or less, with the proviso that the acid is other than hydrochloric acid. Particularly preferred salts are those derived from acids selected from the group comprising sulphonic acid and its derivatives, hydrobromic acid, sulfuric acid, nitric acid and phosphoric acid. The salts in accordance with the invention are particularly suitable for use as photosensitizing agents in diagnosis and photochemotherapy of disorders or abnormalities of external or internal surfaces of the body.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.