Dynamic PET imaging with isotope contamination compensation

US8692681B2 · kind B2 · utility

Assignee

• KONINIKLIJKE PHILIPS N.V. · NL

Inventors

• Herfried Karl Wieczorek · Aachen, DE
• Frank Olaf Thiele · Aachen, DE
• Manoj Narayanan · Mentor, US

Key dates

• Filing date: Jun 15, 2010
• Grant date: Apr 8, 2014
• Expiry date: Dec 4, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B6/037
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A nuclear imaging system includes a scanner (8), such as a PET scanner. A patient is injected with a [13N]ammonia radioisotope tracer which is contaminated with a small percent of 18F contamination. The scanner receives radiation from the injected tracer and a reconstruction processor (28) reconstructs the detected radiation into image representations. A calibration processor (16) generates an estimated decay curve based on the proton bombardment and a priori information about the tracer. An activity meter (42) measures radiation emitted from a sample of the tracer and a dose calibrator (44) determines a decay curve from the measured radiation. The detected radiation is corrected with one of the decay curves during reconstruction or a correction processor (50) corrects reconstructed images with one or both of the decay curves. A display (14) displays uncorrected reconstructed images and the decay curve and/or the corrected images.