Antibodies that inhibit metalloproteins

US8697078B2 · kind B2 · utility

Assignee

• YEDA RESEARCH AND DEVELOPMENT CO. LTD. · IL

Inventors

• Irit Sagi · Rehovot, IL
• Netta Sela-Paswell · Rehovot, IL
• Tamar Danon · Rehovot, IL
• Raanan Margalit · Rehovot, IL

Key dates

• Filing date: Jan 27, 2011
• Grant date: Apr 15, 2014
• Expiry date: Jan 27, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application relates to antibodies which recognize [2(2-aminoethylcarbomoyl)-ethoxymethyl]-tris-[2-N-(3-imidazol-1-yl-propyl))-ethoxymethyl]methane, a hapten molecule which closely mimics the local structure and conformation of the reactive zinc site in matrix metalloproteinases.An antibody is disclosed which comprises an antigen recognition region which comprises six CDR amino acid sequences selected from the group consisting of SEQ ID NOs: 4-15. Uses thereof are also disclosed.