Patent · US Active

Method for producing pharmaceutical drug particles of small particle size

US8697131B2 · kind B2 · utility

3Cited by

4References

3Claims

0Family size

Assignee

Instillo GmbH · DE

Inventors

Akif Emre Tuereli · Saarlouis, DE
Bernd Penth · Lebach, DE
Peter Langguth · Schallstadt, DE
Bernd Baumstuemmler · Saarlouis, DE

Key dates

Filing date	Feb 11, 2010
Grant date	Apr 15, 2014
Priority date	—
Expiry date	Aug 29, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P5/24
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Pharmaceutical drug particles of small particle size are produced by combining a solvent-non-solvent precipitate with an in-situ spray drying process. A pharmaceutical drug is dispersed in a water-miscible solvent, in particular ethanol, and heated in an infeed line under pressure to above the boiling point of the solvent until the drug dissolves. This solution collides as a fine liquid jet with a fine water jet in a gas-permeated microreactor, and the fine mist so arising vaporises rapidly. The organic solvent vaporizes first, then the water. The water may contain surface modifiers.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.