Compositions and methods for producing gamma-carboxylated proteins
US8697440B2 · kind B2 · utility
0Cited by
19References
22Claims
0Family size
Assignee
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Key dates
| Filing date | Nov 19, 2010 |
| Grant date | Apr 15, 2014 |
| Priority date | — |
| Expiry date | Nov 2, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to methods and tools for producing large quantities of gamma-carboxylated protein comprising: (i) culturing a cell adapted to express a protein which requires gamma-carboxylation and γ-glutamyl carboxylase in a ratio of at least 10:1, under conditions suitable for expression of both proteins, and (ii) isolating gamma-carboxylated protein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.