Universal fibronectin type III binding-domain libraries
US8697608B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | Aug 4, 2010 |
| Grant date | Apr 15, 2014 |
| Priority date | — |
| Expiry date | Oct 1, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Walk-through mutagenesis and natural-variant combinatorial fibronectin Type III (FN3) polypeptide libraries are described, along with their method of construction and use. Also disclosed are a number of high binding affinity polypeptides selected by screening the libraries against a variety of selected antigens.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.