Compositions and methods for preventing and treating cancer via modulating UBE1L, ISG215 and/or UBP43
US8697668B2 · kind B2 · utility
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Key dates
| Filing date | Sep 17, 2012 |
| Grant date | Apr 15, 2014 |
| Priority date | — |
| Expiry date | Sep 17, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2799/027
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods of using compositions that induce UBE1L or a ubiquitin-like protein ISG15, or inhibit a deconjugase UBP43 to degrade oncogenic proteins and enhance apoptosis of cancer (neoplastic) or pre-cancerous (pre-neoplastic) cells are provided. Methods for the prevention or treatment of cancer via administration of these compositions are also provided.
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