Bicyclic acetyl-CoA carboxylase inhibitors and uses thereof

US8697739B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• David Barnes · Newton, US
• Gregory Raymond Bebernitz · Stow, US
• Kevin Clairmont · Acton, US
• Scott Louis Cohen · Peabody, US
• Robert E. Damon, II · Cambridge, US
• Robert Day · Watertown, US
• Stephanie Kay Dodd · Ayer, US
• Christoph Gaul · Liestal, CH
• Hatice Belgin GULGEZE EFTHYMIOU · Lynn, US
• Monish JAIN · Cambridge, US
• Rajeshri Ganesh Karki · Somerville, US
• Louise Kirman · Cambridge, US
• Kai Lin · Belmont, US
• Justin Yik Ching Mao · North Reading, US
• Tajesh Jayprakash Patel · Medford, US
• Brian Raymer · Holliston, US
• Liansheng SU · Cambridge, US

Key dates

• Filing date: Jul 25, 2011
• Grant date: Apr 15, 2014
• Expiry date: Dec 22, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y604/01002
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds of formula (I);or pharmaceutically acceptable salts thereof, wherein the variables are defined as herein. The present invention provides a method for manufacturing the compounds of formula (I), their therapeutic uses, combinations with other of pharmacologically active agents, and a pharmaceutical compositions.