Cyclic amide derivative, and its production and use

US8697865B2 · kind B2 · utility

Assignee

• Takeda Pharmaceutical Company Limited · JP

Inventors

• Keiji Kubo · Tsukuba, JP
• Yasuhiro Imaeda · Ann Arbor, US

Key dates

• Filing date: Mar 2, 2010
• Grant date: Apr 15, 2014
• Expiry date: Mar 12, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a cyclic amide derivative useful as a drug for treating thrombosis, which is represented by the formula (I):wherein R1 represents an optionally substituted cyclic hydrocarbon group or an optionally substituted heterocyclic group, W represents a bond or an optionally substituted divalent chain hydrocarbon group, a represents 0, 1, or 2, X1 represents an optionally substituted lower alkylene or an optionally substituted lower alkenylene, Y1 represents —C(O)—, —S(O)— or —S(O)2—, A represents a piperazine ring which may be further substituted or a piperidine ring which may be further substituted, X2 represents a bond or an optionally substituted lower alkylene, Y2 represents —C(O)—, —S(O)—, —S(O)2— or —C(═NR7)—, X3 represents an optionally substituted C1-4 alkylene or an optionally substituted C2-4 alkenylene, Z3 represents —N(R4)—, —O— or a bond, Z1 represents —C(R2) (R2′)—, —N(R2)—, etc., and Z2 represents —C(R3)(R3′)—, —N(R3)—, etc., or a salt thereof.