8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions

US8697868B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Frank Himmelsbach · Mittelbiberach, DE
• Elke Langkopf · Biberach an der Riß, DE
• Matthias Eckhardt · Hannover, DE
• Mohammad Tadayyon · Hertford, GB
• Leo Thomas · Biberach, DE

Key dates

• Filing date: Jan 27, 2009
• Grant date: Apr 15, 2014
• Expiry date: Mar 29, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P19/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are substituted xanthines of the formulawherein R is defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).