Phosphodiesterase inhibitors and uses thereof

US8697875B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Yan Feng · Chengdu, CN
• Ottavio Arancio · New York, US
• Shixian Deng · White Plains, US
• Donald W. Landry · New York, US

Key dates

• Filing date: Jun 23, 2011
• Grant date: Apr 15, 2014
• Expiry date: Jun 23, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D215/54
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides for compounds that are phosphodiesterase inhibitors. The invention further provides for a method for screening compounds that bind to and modulate a phosphosdiesterase protein. The invention also provides methods for treating conditions associated with accumulated amyloid-beta peptide deposit accumulations by administering a phosphodiesterase-binding compound to a subject.