Method for two-dimensional correlation magnetic resonance spectroscopy

US8698496B2 · kind B2 · utility

Assignees

• The General Hospital Corporation · US
• Massachusetts Institute of Technology · US
• The Brigham and Women's Hospital, Inc. · US

Inventors

• Alma Gregory Sorensen · Belmont, US
• Ovidiu Andronesi · Melrose, US
• Carolyn Mountford · Chatswood, AU
• Saadallah Ramadan · Sydney, AU
• Borjan Gagoski · Cambridge, US
• Elfar Adalsteinsson · Belmont, US

Key dates

• Filing date: Sep 20, 2011
• Grant date: Apr 15, 2014
• Expiry date: Oct 9, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G01R33/4633
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Methods for low-power in vivo localized multi-dimensional correlated magnetic resonance spectroscopy (“MRS”) are provided. Low-power adiabaticity is achieved, generally, using gradient-modulated radio frequency pulses for localization and mixing. The provided pulse sequences also provide a mechanism for longitudinal mixing, which significantly increases the efficiency of magnetization transfer and thereby increases signal-to-noise ratio.