Generating artificial hyperspectral images using correlated analysis of co-registered images

US8699769B2 · kind B2 · utility

Assignee

• Definiens GmbH · DE

Inventors

• Ralf Schoenmeyer · Gilching, DE
• Peter Ellenberg · Munich, DE
• Gerd Binnig · Richterswil, CH
• Maria Athelogou · Munich, DE
• Guenter Schmidt · Leun, DE

Key dates

• Filing date: Jul 11, 2012
• Grant date: Apr 15, 2014
• Expiry date: Dec 13, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G06T2207/20221
• WIPO field: Computer technology
• WIPO sector: Electrical engineering

Abstract

High-resolution digital images of adjacent slices of a tissue sample are acquired, and tiles are defined in the images. Values associated with image objects detected in each tile are calculated. The tiles in adjacent images are co-registered. A first hyperspectral image is generated using a first image, and a second hyperspectral image is generated using a second image. A first pixel of the first hyperspectral image has a first pixel value corresponding to a local value obtained using image analysis on a tile in the first image. A second pixel of the second hyperspectral image has a second pixel value corresponding to a local value calculated from a tile in the second image. A third hyperspectral image is generated by combining the first and second hyperspectral images. The third hyperspectral image is then displayed on a computer monitor using a false-color encoding generated using the first and second pixel values.