Resorbable scaffolds for bone repair and long bone tissue engineering
US8702808B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 19, 2009 |
| Grant date | Apr 22, 2014 |
| Priority date | — |
| Expiry date | Mar 23, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/64
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Bioresorbable scaffolds for bone engineering, such as repair of bone defects, particularly long bone defects, or augmentation of bone length are described. Scaffolds are porous and comprise multiple side channels. In one embodiment, scaffolds are made from layers of micro-filament meshes comprising polycaprolactone (PCL) or a PCL-composite sequentially laid in incremental 60 degrees of rotation to produce a 0/60/120 degree layering pattern, providing for the formation of interconnected pores. The scaffold can comprise a central channel filled, packed or infused with suitable agents such as bioactive agents. Furthermore, the scaffolds are stiff but yet fracture resistant and with sufficient bending, compressive and torsional strength suitable for bone engineering. The slow degradation of the scaffold is sufficient for the 3D matrix to maintain structure integrity and mechanical properties during the remodelling process.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.