Biological materials related to c-Met

US8703135B2 · kind B2 · utility

Assignee

• Ablynx N.V. · BE

Inventors

• Gerald Beste · Evergem, BE
• Guy Hermans · Merelbeke, BE
• Soren Steffensen · Woluwe-Saint-Pierre - Sint-Pieters-Woluwe, BE
• Alexander Szyroki · Goldenstedt, DE
• Cedric Jozef Neotere Ververken · Merelbeke, BE
• Tinneke Denayer · Zevergem, BE

Key dates

• Filing date: Mar 30, 2012
• Grant date: Apr 22, 2014
• Expiry date: Mar 30, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to biological materials related to c-Met possibly in combination with VEGF and/or EGFR, and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to host cells expressing or capable of expressing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. Methods and kits for assessing the responsiveness of a patient to c-Met therapy are also described and provided.