Skin repair compositions comprising circadian gene activators and a synergistic combination of Sirt1 gene activators

US8703161B2 · kind B2 · utility

Assignee

• ELC Management LLC · US

Inventors

• Daniel H. Maes · Huntington, US
• Nadine Pernodet · Huntington Station, US
• Thomas Mammone · Farmingdale, US
• Edward Pelle · Valley Stream, US
• Donald F. Collins · Plainview, US
• Lenny Slutsky · Hauppauge, US
• Kerri Goldgraben · Commack, US

Key dates

• Filing date: Jun 23, 2009
• Grant date: Apr 22, 2014
• Expiry date: Nov 19, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61Q19/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions and methods for enhancing repair of damaged DNA in skin cells. Topical compositions comprising at least one agent that upregulates circadian gene expression in skin cells and at least one non-circadian agent that delays mitosis in skin cells. Preferably, such compositions comprise one or more keratinocyte clock and per1 gene activators, along with SIRT1 or one or more sirt1 activators. More preferably, the sirt1 activator is a synergistic combination of specific peptidic sirt1 activators and resveratrol. Preferably, such compositions are easy to use, efficacious, cosmetically acceptable, chemically, thermodynamically and light stable, safe for topical use, have little or no side effects, and commercially feasible in a personal care marketplace.