Multiple growth factor compositions, methods of fabrication, and methods of treatment

US8703180B1 · kind B1 · utility

Assignee

• Abbott Cardiovascular Systems, Inc. · US

Inventors

• John Stankus · Plano, US
• Florian N. Ludwig · Mountain View, US
• Evgenia Mandrusov · Campbell, US
• Liangxuan Zhang · Palo Alto, US
• Hong Ma · Seattle, US
• Jinping Wan · Sunnyvale, US
• Shubhayu Basu · Anaheim, US

Key dates

• Filing date: Oct 23, 2007
• Grant date: Apr 22, 2014
• Expiry date: Nov 3, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/20
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compositions with sustained-release carriers associated with at least two different types of growth factors and methods of fabrication and treatments thereof. In some embodiments, simultaneous release of the growth factors may be preferred while in other embodiments, sequential release of the growth factors may be preferred. Application of at least two growth factors to an injury site, e.g., compromised cardiac tissue caused by, for example, myocardial infarction or ischemic heart failure, may better mimic and induce the complex growth factor signaling pathways necessary to improve cardiac function. When applied to a patient after a myocardial infarction or ischemic heart failure, multiple growth factors within a sustained-release carrier platform or platforms may cause a synergistic effect on injected cells intending to alleviate left ventricle remodeling. Methods of treatment include percutaneous, sub-xiphoid, and open chest methods using catheters and/or syringes.