Abuse-resistant oral dosage forms and method of use thereof
US8703186B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Apr 16, 2013 |
| Grant date | Apr 22, 2014 |
| Priority date | — |
| Expiry date | Apr 16, 2033 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/5026
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An opioid-antagonist oral dosage form which does not release a therapeutically effective amount of the opioid antagonist when the oral dosage form is orally administered to a human being, but whereby a physical alteration of the oral dosage form results in a release of the therapeutically effective amount of the opioid antagonist. An embodiment of the oral dosage form includes an opioid-antagonist layer coated onto a biologically inert pellet, and a non-releasing membrane coated onto the opioid-antagonist layer. Optionally, the oral dosage form can also include an opioid agonist, such that a method of preventing the abuse of an oral dosage form of an opioid agonist is provided by forming the oral dosage form including an opioid agonist and an opioid antagonist.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.