Branched polyamines for delivery of biologically active materials

US8703197B2 · kind B2 · utility

Assignees

• International Business Machines Corporation · US
• AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH · SG

Inventors

• Wei Cheng · Singapore, SG
• Daniel J. Coady · San Jose, US
• Amanda C. Engler · Woodbury, US
• James L. Hedrick · Pleasanton, US
• Pei Yun Teo · Singapore, SG
• Chuan Yang · Singapore, SG
• Yi Yan Yang · Singapore, SG

Key dates

• Filing date: Sep 13, 2012
• Grant date: Apr 22, 2014
• Expiry date: Sep 13, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G73/028
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A branched polyamine comprises about 45 to about 70 backbone tertiary amine groups, about 90 to about 140 backbone secondary amine groups, a positive number n′ greater than 0 of backbone terminating primary amine groups, and a positive number q greater than 0 of backbone terminating carbamate groups of formula (2):wherein (n′+q) is a number equal to about 45 to about 70, the starred bond of formula (2) is linked to a backbone nitrogen of the branched polyamine, L′ is a divalent radical comprising 3 to 30 carbons, and q/(n′+q)×100% equals about 9% to about 47%.