Non-invasive diagnosis of graft rejection in organ transplant patients

US8703652B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Stephen R. Quake · Pasadena, US
• Thomas M. Snyder · Laceyville, US
• Hannah Valantine · Stanford, US

Key dates

• Filing date: Nov 5, 2010
• Grant date: Apr 22, 2014
• Expiry date: Nov 5, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/156
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The disclosure provides methods, devices, compositions and kits for diagnosing or predicting transplant status or outcome in a subject who has received a transplant. The methods comprise determining the presence or absence of one or more nucleic acids from a donor transplant, wherein said one or more nucleic acids from said donor are identified based on a predetermined marker profile, and diagnosing or predicting transplant status or outcome based on the presence or absence of said one or more nucleic acids.