Dipeptoid prodrugs and the use thereof

US8703696B2 · kind B2 · utility

Assignee

• Bayer Intellectual Property GmbH · DE

Inventors

• Hans-Georg Lerchen · Leverkusen, DE
• Ursula Krenz · Leichlingen, DE
• Joerg Keldenich · Wuppertal, DE
• Nicole Diedrichs · Wuppertal, DE
• Thomas Krahn · Hagen, DE
• Claudia Hirth-Dietrich · Wuppertal, DE
• Barbara Albrecht-Küpper · Uerdingen, DE

Key dates

• Filing date: Jul 23, 2008
• Grant date: Apr 22, 2014
• Expiry date: Feb 15, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/06086
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application relates to prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.