Monomethylvaline compounds capable of conjugation to ligands
US8703714B2 · kind B2 · utility
50Cited by
78References
48Claims
0Family size
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Key dates
| Filing date | Apr 29, 2011 |
| Grant date | Apr 22, 2014 |
| Priority date | — |
| Expiry date | Aug 13, 2031 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/13
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.