Process for the preparation of aryl substituted olefinic amines

US8703802B2 · kind B2 · utility

Assignee

• Targacept, Inc. · US

Inventors

• Gary Maurice Dull · Lewisville, US
• John Genus · Winston-Salem, US
• Tommi Ratilainen · Gately Drive, SE
• Per Olof Ryberg · Malung, SE
• Janna Hellström · Macclesfield, GB
• Niklas Wahlstrom · Macclesfield, GB
• Thomas Wannman · Gately Drive, SE

Key dates

• Filing date: May 19, 2011
• Grant date: Apr 22, 2014
• Expiry date: May 19, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C269/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An improved process for the preparation of aryl substituted olefinic amines such as (2S)-(4E)-N-methyl-5-[3-(5-isopropoxypyridin)yl]-4-penten-2-amine and (2S)-(4E)-N-methyl-5-[3-(5-methoxypyridin)yl]-4-penten-2-amine and new intermediates used in said process.