Isolated monoclonal antibody or fragment thereof binding prostate specific membrane antigen, conjugates and uses thereof

US8703918B2 · kind B2 · utility

Assignees

• UNIVERSITA' DEGLI STUDI DI VERONA · IT
• Fondazione IRCCS Istituto Nazionale Dei Tumori · IT
• Marco Colombatti · IT

Inventors

• Marco Colombatti · Varallo, IT
• Giulio Fracasso · Verona, IT
• Sara Cingarlini · Verona, IT
• Silvana Canevari · Segrate, IT
• Mariangela Figini · Milano, IT

Key dates

• Filing date: Apr 22, 2009
• Grant date: Apr 22, 2014
• Expiry date: May 20, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An isolated monoclonal antibody or fragment thereof binding prostate specific membrane antigen (PSMA) preferably in its native form on the surface of tumour cells. A conjugate of the antibody with an active ingredient and modified forms of the antigen-binding antibody fragment are also provided. The complete antibody and the antigen-recognising fragment thereof are used alone or conjugated for the treatment and the diagnosis of tumours or tissues associated to the tumour overexpressing the PSMA antigen, preferably prostatic neoplastic diseases.