Patent · US Active

Derivative N-thiolated 2-oxazolidinone antibiotics

US8703963B2 · kind B2 · utility

0Cited by

1References

9Claims

0Family size

Assignee

University of South Florida · US

Inventors

Edward Turos · Tampa, US
Rajesh Kumar Mishra · Needham, US
Kevin D. Revell · Murray, US
Cristina M. Coates · Tampa, US

Key dates

Filing date	Feb 8, 2008
Grant date	Apr 22, 2014
Priority date	—
Expiry date	Aug 29, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D263/52
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

This invention describes the discovery and synthesis of N-thiolated 2-oxazolidinones as a new class of anti bacterial agents. These compounds can be synthesized from 2-oxazolidinones by Ndeprotection and N-sulfenylation. These new substances were found to exhibit potent anti-bacterial activity, including bacteriostatic properties against Staphylococcus spp., including methicillin resistant Staphylcoccus aureus (MRSA), and Bacillus spp., including Bacillus anthracis.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.