Persistent luminescence nanoparticles used in the form of a diagnosis agent for in vivo optical imaging
US8709383B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 30, 2006 |
| Grant date | Apr 29, 2014 |
| Priority date | — |
| Expiry date | Jul 16, 2029 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB82Y15/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to using persistent luminescence nanoparticles, functionalised if necessary, in the form of an diagnosis agent for an in vivo optical imaging. Said nanoparticles are preferably consist of a compound selected from a group comprising (1) silicates, aluminates, aluminosilicates, germanates, titanates, oxysulphides, phosphates and vanadates, wherein said compounds contain at least one type of metal oxide, (2) the sulphides comprise at least one metal ion selected from zinc, strontium and calcium, and (3) metal oxides, wherein said compounds is doped with at least one rare earth ion, and possibly with at least one transition metal ion. In a preferred embodiment, the diagnosis agent is used for an organism vascularization imaging. A method and kit for detecting or quantifying in vitro a substance of biological or chemical interest in a sample by using said pre-functionalised nanoparticles are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.