Anti-prion protein antibody fragment

US8709410B2 · kind B2 · utility

Assignees

• Carsten Korth · DE
• Lothar Stitz · DE
• Benjamin Petsch · DE
• Andreas Müller-Schiffmann · DE

Inventors

• Carsten Korth · Zürich, CH
• Lothar Stitz · Rottenburg am Neckar, DE
• Benjamin PETSCH · Tübingen, DE
• Andreas Müller-Schiffmann · Odenthal, DE
• Sirik Rutger Leliveld · Düsseldorf, DE

Key dates

• Filing date: Jun 16, 2009
• Grant date: Apr 29, 2014
• Expiry date: Apr 16, 2030

Classification

• Technology area (CPC —): General

Abstract

The invention relates to an antibody, antibody fragment or derivative thereof which specifically recognizes a prion protein and which comprises a complementarity determining region (CDR), a retro-inverso D-peptide of said CDR and/or an anti-idiotypic antibody, antibody fragment or derivative thereof which recognizes said CDR. The invention further concerns a nucleic acid molecule encoding said antibody, antibody fragment or derivative thereof as well as a method for generating an antibody, antibody fragment or derivative thereof that specifically recognizes a prion protein, wherein an antibody that recognizes a specific domain of the prion protein is generated, an antigen-specific amino acid sequence is isolated from said antibody, and an anti-idiotypic antibody, antibody fragment or derivative thereof, which recognizes said antigen-specific amino acid sequence, is generated.