Compositions of PD-1 antagonists and methods of use
US8709416B2 · kind B2 · utility
86Cited by
92References
28Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 20, 2011 |
| Grant date | Apr 29, 2014 |
| Priority date | — |
| Expiry date | Dec 20, 2031 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods of treating cancer and infectious diseases utilizing a treatment regimen comprising administering a compound that reduces inhibitory signal transduction in T cells, in combination with a potentiating agent, such as cyclophosphamide, to produce potent T cell mediated responses, are described. Compositions comprising the PD-1 antagonists and potentiating agents useful in the methods of the invention are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.