Hypallergenic mosaic antigens and methods of making same

US8709435B2 · kind B2 · utility

Assignee

• BIOMAY AG · AT

Inventors

• Raffaela Campana · Wien, AT
• Rudolf Valenta · Theresienfeld, AT
• Susanne Vrtala · Wien, AT
• Ines Swoboda · Wien, AT
• Margarete Focke-Tejkl · Wien, AT
• Anna Gieras · Wien, AT
• Susanne Spitzauer · Wien, AT
• Peter Valent · Wien, AT
• Katharina Blatt
• Birgit Linhart · Neunkirchen, AT
• Dietrich Kraft · Wien, AT

Key dates

• Filing date: Jul 8, 2011
• Grant date: Apr 29, 2014
• Expiry date: Jul 8, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/76
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Hypoallergenic mosaic antigens assembled from naturally-occurring allergens are disclosed herein. Also disclosed are methods of making such hypoallergenic mosaic antigens, particularly those derived from plant allergens such as timothy grass pollen (Phl p 1 and Phl p 2) and birch pollen (Bet v 1). In a particularly preferred embodiment, the method of making the hypoallergenic mosaic antigen involves the steps of (a) cleaving a naturally-occurring allergen into at least two, preferably at least three non-overlapping peptide fragments and (b) recombining the peptide fragments such that the mosaic antigen includes all or substantially all of the amino acids of the original naturally-occurring allergen, though in a different order.