Clostridium chauvoei polypeptide, DNA encoding the polypeptide and a vaccine comprising the polypeptide
US8709437B2 · kind B2 · utility
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Key dates
| Filing date | Jan 28, 2010 |
| Grant date | Apr 29, 2014 |
| Priority date | — |
| Expiry date | Jan 28, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention pertains to the identification and initial characterization of CctA, a novel, secreted toxin of Clostridium chauvoei that represents the major cytotoxic activity of C. chauvoei. This toxin confers C. chauvoei its characteristic strong hemolytic activity towards erythrocytes of various species, since anti-CctA antibodies fully neutralize hemolysis by C. chauvoei on standard blood-agar medium or in cell-free supernatants of liquid cultures.
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