Compositions substantially free of sodium chloride and methods for the storage of red blood cells
US8709707B2 · kind B2 · utility
1Cited by
16References
17Claims
0Family size
Inventors
Key dates
| Filing date | Sep 10, 2012 |
| Grant date | Apr 29, 2014 |
| Priority date | — |
| Expiry date | Sep 10, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N5/0641
- WIPO fieldBasic materials chemistry
- WIPO sectorChemistry
Abstract
The present invention provides an aqueous composition for storage of red blood cells consisting essentially of: adenine; dextrose; at least one nonmetabolizable membrane-protectant sugar; and a specifically defined pH buffering system. Also provided are improved methods for preserving red blood cells and methods for increasing the viability, membrane retention, and recoverability while suppressing apoptosis, hemolysis, and post-reinfusion clearance of stored red blood cells which utilize the novel compositions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.