Magnetic detection of small entities

US8709727B2 · kind B2 · utility

Inventors

• Mattias Strömberg · Uppsala, SE
• Jenny Goransson · Uppsala, SE
• Klas Gunnarsson · Uppsala, SE
• Mats Nilsson · Lund, SE
• Peter Svedlindh · Uppsala, SE
• Maria Strçmme · Uppsala, SE

Key dates

• Filing date: Sep 17, 2008
• Grant date: Apr 29, 2014
• Expiry date: Jun 17, 2030

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2458/10
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A novel detection or quantifying method for biological entities or molecules such as, but not limited to, DNA, microorganisms and pathogens, proteins and antibodies, that by themselves are target molecules or from which target molecules are extracted, comprises the steps of i) forming target molecule-dependent volume-amplified entities, ii) allowing magnetic nanoparticles to bind to said volume-amplified entities, and iii) measuring changes in dynamic magnetic response of the magnetic nanoparticles caused by the increase in hydrodynamic volume of said magnetic nanoparticles.