Methods of preventing and treating viral infections by inhibiting the deISGylation activity of OTU domain-containing viral proteins
US8709730B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Apr 7, 2008 |
| Grant date | Apr 29, 2014 |
| Priority date | — |
| Expiry date | Jan 25, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/10022
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Viruses having an impaired ability to deISGylate ISG15 conjugates, in particular, viral mutants comprising a mutation in the viral genome that reduces or eliminates the ability of the viral OTU domain-containing protein encoded by the viral genome to deISGylate ISG15 conjugates and/or deubiquitinate ubiquitinated proteins and/or deNeddylate Neddylated proteins are disclosed. Such viral mutants may be used in the formulation of immunogenic compositions for inducing an immune response and preventing, managing and/or treating a viral infection. Also disclosed are methods for identifying anti-viral compounds, in particular, methods of identifying compounds that reduce or inhibit the deISGylation activity and/or deubiquitination and/or deNeddylation activity of a viral OTU domain-containing protein. The compounds identified using such methods may be used as antiviral agents for the prevention, treatment and/or management of viral infections.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.