Preparation of isomerically pure substituted cyclohexanols

US8709751B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Melanie Bonnekessel · Mannheim, DE
• Klaus Ditrich · Neheim, DE
• Jürgen Däuwel · Heidelberg, DE
• Achim Sorg · Mannheim, DE
• Wolfgang Ladner
• Bryan Cooper · Mannheim, DE
• Rene Backes · Lampertheim, DE

Key dates

• Filing date: Nov 23, 2011
• Grant date: Apr 29, 2014
• Expiry date: Feb 19, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P41/004
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention relates to the preparation of isomerically pure substituted cyclohexanols starting from a mixture of cis/trans substituted cyclohexanols which comprises reacting the cis/trans mixture of a substituted cyclohexanol with a dicarboxylic acid anhydride in the presence of a lipase, to give the trans semi-ester which is separated off from the unreacted substituted cyclohexanol cis isomer.