Patent · US Active

Lipoprotein analysis by differential charged-particle mobility

US8709818B2 · kind B2 · utility

3Cited by

28References

9Claims

0Family size

Assignee

Quest Diagnostics Investments LLC · US

Inventors

Michael P. Caulfield · San Clemente, US
Richard E. Reitz · San Clemente, US
Shuguang Li · Rancho Santa Margarita, US
Gloria Kwangja Lee · Irvine, US
Ronald M. Krauss · Berkeley, US
Patricia J. Blanche · Berkeley, US
W. Henry Benner · Danville, US
Earl Cornell · Antioch, US

Key dates

Filing date	Aug 20, 2012
Grant date	Apr 29, 2014
Priority date	—
Expiry date	Aug 20, 2032

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10T436/25375
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The invention provides methods of preparation of lipoproteins from a biological sample, including HDL, LDL, Lp(a), IDL, and VLDL, for diagnostic purposes utilizing differential charged particle mobility analysis methods. Further provided are methods for analyzing the size distribution of lipoproteins by differential charged particle mobility, which lipoproteins are prepared by methods of the invention. Further provided are methods for assessing lipid-related health risk, cardiovascular condition, risk of cardiovascular disease, and responsiveness to a therapeutic intervention, which methods utilize lipoprotein size distributions determined by methods of the invention.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.