Imidazo[1,2-B]pyridazine and pyrazolo[1 .5-A]pyrimidine derivatives and their use as protein kinase inhibitors

US8710057B2 · kind B2 · utility

Assignee

• TOLERO PHARMACEUTICALS, INC. · US

Inventors

• David J. Bearss · Alpine, US
• Xiao-Hui Liu · Holladay, US
• Hariprasad Vankayalapati · Draper, US
• Yong Xu · Midvale, US

Key dates

• Filing date: Jul 21, 2011
• Grant date: Apr 29, 2014
• Expiry date: Jul 21, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides protein kinase inhibitors comprising imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine compounds of the following structure (I) and (II):or a stereoisomer, prodrug or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer and other Pim kinase-associated conditions are also disclosed.