Method of treating cancer using a survivin inhibitor

US8710068B2 · kind B2 · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• Alan Berezov · Glenolden, US
• Qiang Wang · Philadelphia, US
• Ramachandran Murali · Swarthmore, US
• Mark I. Greene · Levittown, US

Key dates

• Filing date: Jan 19, 2010
• Grant date: Apr 29, 2014
• Expiry date: May 13, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are methods of treating cancer by administering to a patient a small molecule inhibitor of Survivin. Also disclosed herein are methods of inhibiting Survivin dimerization in a patient by administering a compound of formula (I), (II), (III), or (IV). Methods of inducing cell cycle arrest in cancer cells, comprising G2/M stage arrest, in a patient by administering a compound of formula (I), (II), (III), or (IV) are also disclosed. Further disclosed herein are methods of inducing apoptosis in cancer cells in a patient by administering a compound of formula (I), (II), (III), or (IV).