Compounds, compositions and methods for reducing lipid levels
US8710071B2 · kind B2 · utility
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4References
40Claims
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Key dates
| Filing date | Dec 22, 2009 |
| Grant date | Apr 29, 2014 |
| Priority date | — |
| Expiry date | Sep 12, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D495/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present technology relates to compounds of Formulas (V) and methods of making and using such compounds. Methods of use include prevention and treatment of hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, and metabolic syndrome. Compounds disclosed herein also lower total cholesterol, LDL-cholesterol, and triglycerides and increase hepatic LDL receptor expression, inhibit PCSK9 expression, and activate AMP-activated protein kinase.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.