Catecholic butanes and use thereof for cancer therapy
US8710104B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 6, 2009 |
| Grant date | Apr 29, 2014 |
| Priority date | — |
| Expiry date | Feb 4, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/74
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present application relates to compositions and methods for treating a proliferative disorder by administering to a subject a pharmaceutical composition of a dual kinase inhibitor. Catecholic butanes cane serve as dual kinase inhibitors for purposes of methods described herein. Subjects can be further treated by co-administering an EGFR inhibitor. The present application also relates to analyzing a sample with respect to levels of IGF-1R and EGFR and comparing levels of IGF-1R and EGFR to a control. Patients can be selected for treatment with a catecholic butane based on the assessment; optionally, patients can be further treated with an EGFR inhibitor, an IGF-1R inhibitor, or both.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.