Method of preparing enteric hard capsule and enteric hard capsule prepared thereby
US8710105B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 21, 2011 |
| Grant date | Apr 29, 2014 |
| Priority date | — |
| Expiry date | Apr 13, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/4816
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method of preparing enteric hard capsules, and an enteric hard capsule prepared by the method. The method may include: dissolving an enteric base material, a capsule forming aid, and a neutralizing agent in water at room temperature to prepare an aqueous composition; heating the aqueous composition to a first temperature that is higher than a gelation start temperature of the aqueous composition; cooling the heated aqueous composition to a second temperature that is lower than the gelation start temperature; immersing a mold pin heated to a third temperature that is higher than the gelation start temperature into the aqueous composition; removing the mold pin from the aqueous composition to obtain a film coated on the mold pin; maintaining the film on the mold pin at a fourth temperature that is higher than the gelation start temperature for a first time period to fix the film onto the mold pin; and drying the fixed film at a fifth temperature for a second time period to obtain a capsule shell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.