Use of tris(hydroxymethyl) aminomethane for the stabilization of peptides, polypeptides and proteins
US8710181B2 · kind B2 · utility
15Cited by
22References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 26, 2005 |
| Grant date | Apr 29, 2014 |
| Priority date | — |
| Expiry date | Sep 27, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K1/113
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention is directed to a method for reducing the onset or incidence of gelation/fibrillation/aggregation during the up- and down-stream processing and purification of peptides, polypeptides and proteins analogs and/or derivatives thereof, including Glucagon-Like Peptides (GLPs). More particularly, the present invention relates to methods of processing and purifying such peptides, polypeptides and proteins in the presence of tris(hydroxymethyl)aminomethane.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.