Method for identification, isolation and production of antigens to a specific pathogen

US8715688B2 · kind B2 · utility

Assignee

• Valneva Austria GmbH · AT

Inventors

• Andreas Meinke · Pressbaum, AT
• Eszter Nagy · Wien, AT
• Uwe Von Ahsen · Wien, AT
• Christoph Klade · Wien, AT
• Tamas Henics · Wien, AT
• Wolfgang Zauner · Wien, AT
• Duc Bui Minh · Wien, AT
• Oresta Vytvytska · Wien, AT
• Hildegard Etz · Wien, AT
• Agnieszka Dryla · Wien, AT
• Thomas Weichhart · Böheimkirchen, AT
• Martin Hafner · Wien, AT
• Brigitte Tempelmaier · Wien, AT
• Claire Fraser · Centreville, US
• Steven Gill · Frederick, US

Key dates

• Filing date: Sep 13, 2012
• Grant date: May 6, 2014
• Expiry date: Sep 13, 2032

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described is a method for identification, isolation and production of hyperimmune serum-reactive antigens from a specific pathogen, a tumor, an allergen or a tissue or host prone to auto-immunity, said antigens being suited for use in a vaccine for a given type of animal or for humans, which is characterized by the following steps: providing an antibody preparation, providing at least one expression library, identifying antigens which bind, screening the identified antigens, identifying the hyperimmune serum-reactive antigen portion of said identified antigens and which hyperimmune serum-reactive antigens bind to a relevant portion of said individual antibody optionally isolating said hyperimmune serum-reactive antigens and producing said hyperimmune serum-reactive antigens by chemical or recombinant methods.