Methods of obtaining a specific binding member that binds eotaxin

US8715961B2 · kind B2 · utility

Assignee

• MedImmune Limited · US

Inventors

• Tristan Vaughan · Cambridge, GB
• Alison J. Wilton · Cambridge, GB
• Stephen J. Smith · Los Gatos, US
• Sarah Helen Main · Royston, GB

Key dates

• Filing date: Oct 19, 2011
• Grant date: May 6, 2014
• Expiry date: Jan 9, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Specific binding members directed to eotaxin-1, in particular human antibodies and antibody fragments against human eotaxin-1 and especially those which neutralize eotaxin-1 activity. The antibodies VH and/or VL domain of the scFv fragment herein termed CAT-212 and of the IgG4 antibody herein termed CAT 213. One or more complementary determining regions (CDRs) of the CAT-212-213 VH and/or VL domains, especially VH CRD3 in other antibody framework regions. Compositions containing specific binding members, and their use in methods of inhibiting or neutralizing eotaxin, including methods of treatment of the human or animal body by therapy.