Antibody ultrahumanization by predicted mature CDR blasting and cohort library generation and screening
US8716195B2 · kind B2 · utility
7Cited by
7References
2Claims
0Family size
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Key dates
| Filing date | Nov 10, 2006 |
| Grant date | May 6, 2014 |
| Priority date | — |
| Expiry date | May 14, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/622
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods and compositions directed to improved universal antibody libraries that rationally exploit human diversity information contained within reference antibody libraries, such as universal antibody libraries, are disclosed. The disclosed processes involve use of a query CDR sequence to guide incorporation of human antibody diversity present within the reference library into cohort libraries of the invention. Methods for making and screening such cohort libraries for isolating therapeutics suitable for treating disease are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.