Methods for treatment or prevention of diseases associated with functional disorder of regulatory T cells
US8716230B2 · kind B2 · utility
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2Claims
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Assignee
Inventors
Key dates
| Filing date | Oct 12, 2010 |
| Grant date | May 6, 2014 |
| Priority date | — |
| Expiry date | Oct 12, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The inventors examined the role of MK in experimental autoimmune encephalomyelitis, which is a human model for multiple sclerosis. As a result, they discovered that MK has the effect of inhibiting regulatory T cells, and that the autoimmune mechanism induced by type 1 helper T cells can be suppressed by inhibiting MK expression or its activity, thereby increasing the number of regulatory T cells. Furthermore, it was found that diseases associated with the functional disorder of regulatory T cells can be treated with the administration of an inhibitor that inhibits MK expression or activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.