NOTCH mutations leading to increased receptor signaling

US8716233B2 · kind B2 · utility

Assignees

• The Brigham and Women's Hospital, Inc. · US
• DANA-FARBER CANCER INSTITUTE, INC. · US

Inventors

• Jon Aster · Lexington, US
• Stephen Blacklow · Cambridge, US
• A. Thomas Look · North Reading, US
• Adolfo A. Ferrando · New York, US
• Andrew P. Weng · Vancouver, CA

Key dates

• Filing date: May 22, 2009
• Grant date: May 6, 2014
• Expiry date: Sep 11, 2030

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/70567
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention is based upon the identification of regions within the NOTCH-1 receptor that, when mutated, lead to increase receptor signaling. The mutations are associated with uncontrolled cellular growth and this growth may be arrested using agents that interfere with NOTCH-1 activity, such as inhibitors of gamma-secretase. Assays for the NOTCH-1 mutations may be used diagnostically or as part of a treatment regimen for cancer patients.