Microrna compositions and methods for the treatment of myelogenous leukemia
US8716255B2 · kind B2 · utility
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10References
14Claims
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Key dates
| Filing date | Aug 11, 2008 |
| Grant date | May 6, 2014 |
| Priority date | — |
| Expiry date | Jan 19, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/141
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides methods, uses, kits and compositions comprising a therapeutically effective amount of the microRNA miR-223 for treating myelogenous leukemia in a subject in need of such treatment. The invention further comprises methods encompassing the use of miR-223 for promoting the differentiation of a leukemia stem cell that is resistant to a differentiating agent, and a method of screening for candidate compounds capable of treating a myeloid leukemia by comparison of the therapeutic activity of the candidate compound with the therapeutic activity of miR-233.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.